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When we only take vitamins, minerals and herbs, as important as they are, we are skirting around the outside of the essentials for health. If we just take supplements and not replace the enzymes we are wasting a good bit of money, expectation and time.
If we don't have healthy levels of sexual hormones (i.e. progesterone and testosterone) then we cannot maintain our bone and muscle density; we'll be depressed, gain fat and have no drive for life.
If we don't maintain our frame, through exercise then we can forget the rest of the program as it will give out regardless of whatever else we do.
So again the cornerstones of life and wellness are: enzymes, zinc, magnesium, hormones and exercise.