**Please note that Pygeum Africanum Bark is from a tree that has been on the endangered species list for quite some time due to the increased demand for the raw material. As a result, it is becoming more and more difficult to find this raw material as sources dry up. For now, we have still been able to obtain the Pygeum Africanum Bark Extract that is used in the Sinest® product but prices are soaring due its limited availability and it may not be available for much longer. We will endeavor to continue to manufacture this product for as long as we can find the raw material. Looking forward, Dr. Wong is attempting to find an alternative replacement material that has the same function just in case this material becomes unavailable. Thank you, we appreciate your patience and understanding**.
Dr. Wong's Essentials® Sinest® is a preparation of proven estrogen blocking or aromatase inhibiting agents to either block the action of estrogen in the body or block the making of estradiol and estrone, the two most dangerous and carcinogenic forms of estrogen.* While many supplements have these ingredients, they are normally not found in a dosage sufficient to have a physiological effect. According to the head of hormone research at Georgetown University, these herbs only have the anti-estrogenic actions when taken in doses above 1 gram (1000mg) of the raw powdered herbs. In creating Sinest®, full strength extracts of the component herbs were used and combined so that in a single caplet there is the equivalent of over a teaspoon (5000 mg) of each herb.
Pygeum Africanum Bark Extract
Pygeum africanum bark has been used medicinally for thousands of years to treat bladder and urination disorders, especially with those symptoms associated with an enlarged prostate.
"Pygeum has been observed to moderately improve urinary symptoms associated with enlargement of the prostate gland or prostate inflammation. Numerous human studies report that pygeum significantly reduces urinary hesitance, urinary frequency, the number of times patients need to wake up at night to urinate, and pain with urination".*
WebMD states "...Pygeum contains chemicals that help shrink the prostate to relieve urinary problems such as poor urine flow and nighttime urination in men with enlarged prostates."*
Chrysin has been reported to be an aromatase inhibitor as well as as a testosterone booster.* It has also been thought to have some anti-inflammatory effects.*
New studies may indicate that Chrysin may be used to protect and normalize age-related cognitive decline.*
Nettle Root Extract
Nettle root extracts have been studies in human clinical trials as a treatment for benign prostatic hyperplasia (BPH).* It is also used in body building to increase free testosterone.* Resent studies indicate that Stinging Nettle Root extracts may have anti-inflammatory benefits especially for arthritis conditions.*
Serrapeptidase Serrapeptidase helps absorption and enhances the benefits of the herbs in the blend.